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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

Acutely toxic for aquatic invertebrates

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
6.94 mg/L

Additional information

To determine the short-term toxicity of N,N,N',N'-Tetramethylhexamethylenediamine (TMHDA; CAS 111 -18 -2) to aquatic invertebrates, a 48-hr acute Daphnia magna toxicity study was conducted according to EPA guideline 797.1300. Nominal test concentrations ranged from 0.313 mg/L to 20.0 mg/L. The test system was semi-static, as test solutions were renewed after 24 hours. Adjustment of pH was not specfied, but pH ranged between 7.6 and 7.9. The number of immobile animals in each test vessel as well as any abnormal behaviour were recorded at 0, 24 , and 48 hours. The 48 -hour EC50 was estimated to be 6.94 mg/L based on measured concentrations (Danish EPA 2000; report no. 81089/270).

In conclusion, TMHDA is considered to be acutely toxic for aquatic invertebrates.