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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Purity and physical chemical properties of test substance not given, age of animals not given, concentration in air not analytically verified.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Exposure for 4 hours to one concentration with 14 days postdosing observation period, one group of 5 males and 5 females, particle size distribution determined, mortality, bodyweights, and gross pathology recorded
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,6,7,8,9,14,15,16,17,17,18,18-dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene
EC Number:
236-948-9
EC Name:
1,6,7,8,9,14,15,16,17,17,18,18-dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene
Cas Number:
13560-89-9
Molecular formula:
C18H12Cl12
IUPAC Name:
1,2,3,4,7,8,9,10,13,13,14,14-dodecachloro-1,4,4a,5,6,6a,7,10,10a,11,12,12a-dodecahydro-1,4:7,10-dimethanodibenzo[a,e][8]annulene
Test material form:
solid: particulate/powder
Details on test material:
Dechlorane Plus 25: particle size distribution 56.8% at 1-5 µm, 10.2% at 6-10 µm, 14.8% at 11-25 µm, 18.2% at >25 µm.

Test animals

Species:
rat
Strain:
other: Charles River
Sex:
male/female
Details on test animals or test system and environmental conditions:
No further details reported.

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
clean air
Details on inhalation exposure:
Particle size distribution 56.8% at 1-5 µm, 10.2% at 6-10 µm, 14.8% at 11-25 µm, 18.2% at >25 µm, exposure for 4 hours, no further details reported.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
2.25 mg/l
No. of animals per sex per dose:
5 males and 5 females
Control animals:
no
Details on study design:
4 hours exposure, 14 days postexposure observation time, mortality, bodyweight, and gross pathology were recorded. No further details reported.
Statistics:
none

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 2.25 mg/L air (nominal)
Based on:
act. ingr.
Exp. duration:
4 h
Remarks on result:
other: no mortality, no effects on bodyweights, no changes in gross pathology
Mortality:
none
Clinical signs:
other: none reported
Body weight:
no effects
Gross pathology:
no effects
Other findings:
no other findings

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Not toxic at a concentration of 2.25 mg/l in air as dust upon 4 hours of inhalation.
Executive summary:

Groups of 5 male and 5 female rats were exposed by inhalation to Dechlorane Plus 25 at a concentration of 2.25 mg/l as dust in air for 4 hours. No treatment-related effects were observed. The NOEL was determined at 2.25 mg/l. Dechlorane Plus 25 was not toxic by inhalation.