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EC number: 414-110-5 | CAS number: 1379678-96-2 ORASOL BLAU 761B
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 values for acute exposure to the test item (described in section 1.2) by the oral or dermal route are > 2000 mg/kg bw (OECD 401 and 402, GLP). No mortality occured.
Key value for chemical safety assessment
Additional information
Acute toxicity: oral route
In an acute oral toxicity study (RCC Notox BV, 1993), groups of young adult Wistar rats (5 animals/sex) were given a single oral gavage dose of the test item in propylene glycol at 2000 mg/kg bw (dose volume: 10 mL/kg bw) and observed for 15 days. There was no mortality or changes in body weight noted during the study period. Clinical signs observed among all animals included blue discoloured faeces, salivation and hunched posture. These symptoms had disappeared in all animals at day 12 of the observation period. At necropsy, greyish discolouration of abdominal fat and enlarged stomach with watery contents were noted in females only. Under the conditions of this study, the oral LD 50 for male and female rats was >2000 mg/kg bw.
Acute toxicity: dermal route
In an acute dermal toxicity study (RCC Notox BV, 1993), groups of fasted young adult Wistar rats (5 animals/sex) were dermally exposed to the test item in propylene glycol at 2000 mg/kg bw (dose volume: 10 mL/kg bw) for 24 hours. Animals then were observed for 15 days. No mortality and no treatment related clinical signs were observed during the study period. Body weights were only affected during the first observation week. Bluish discolouration was seen in the snout, tail, treated skin and surrounding area as well as abdominal fat. Thus, under the conditions of this study, the dermal LD50 for males and females was >2000 mg/kg bw.
Justification for classification or non-classification
Based on the results of the acute oral and dermal key toxicity studies, the test item is not subject to classification and labelling for acute toxic effects according to Directive 67/548/EEC and Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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