Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The experimental design was performed according to the method of B. Magnusson and A.M. Kligman (OECD / EEC-guidelines).

To test the sensitising properties of the compound 20 test- and 20 control-animals (guinea-pigs) were treated with 10 % of the test compound during the induction phases (intradermal and dermal) and with 1 % for the challenge (dermal) using Freund's Complet Adjuvant (FCA) to intensify the immunological reaction.

Any signs of erythema and edema were recorded 24 h and 48 h after the challenge.

According to the method of B. Magnusson and A.M. Kligman (OECD / EEC-guidelines), the compound "CITROWANIL B" is considered not to cause any hypersensitivity in guinea-pigs.

Migrated from Short description of key information:
Citrowanil B does not have skin sensitisation properties.

Justification for classification or non-classification