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Short-term toxicity to aquatic invertebrates

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Description of key information

EC50 (48 h): > 100 mg/L for Daphnia magna (nominal; OECD 202)

Key value for chemical safety assessment

Additional information

One experimental study investigating the short-term toxicity of ethylene diformate (CAS 629-15-2) to aquatic invertebrates is available (Vryenhoef, 2012). The study was performed according to OECD 202 under GLP conditions using the water flea Daphnia magna. A range-finding study with three concentrations up to 100 mg/L did not result in any immobility after 48 h. Thus, a confirmatory limit test with 100 mg/L was performed under static conditions. The substance was found to hydrolyse in test medium with an approximate half-life of 11 h. The analytical measurement with gas chromatography (GC) revealed a decline in test concentration. Therefore, the possible effects of the parent substance and the hydrolysis products were tested in this study. After an exposure of 48 h, an EC50 of > 100 mg/L and a NOEC of ≥ 100 mg/L resulted. Given that complete hydrolysis of the parent test item did not occur, and that toxicity cannot be attributed to the parent test item, the degradation product, or a mixture of the two, it was considered appropriate to calculate the results based on nominal parent test item concentrations only. Based on the result of this test, it is not expected that ethylene diformate and its hydrolysis products will exhibit acute toxic effects to aquatic invertebrates.