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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
8.01.1992-29.01.1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-dichloroaniline
EC Number:
210-157-9
EC Name:
2,3-dichloroaniline
Cas Number:
608-27-5
Molecular formula:
C6H5Cl2N
IUPAC Name:
2,3-dichloroaniline
Constituent 2
Reference substance name:
2,3-dichlorobenzene
IUPAC Name:
2,3-dichlorobenzene
Details on test material:
- Name of test material (as cited in study report): 2.3-dichloroaniline
- Physical state: solid
- Analytical purity: 99.5 %
- Impurities (identity and concentrations): 0.02% 3.chloraniline, 0.14% 3,4-dichloraniline, 0.29% unknown substances
- Storage condition of test material: Room temperature/in the dark

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose/head only
Vehicle:
other: air
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
0, 809, 8047 mg/m³ and air control
No. of animals per sex per dose:
10
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 8 047 mg/m³ air
Exp. duration:
4 h

Any other information on results incl. tables

no mortality

clinical signs at 8047 mg/m³ in males and females:
-unspecific signs: rough and unkempt fur, reduced motility, staggering gait, tremor, atony, coma, body weight loss
-some animals with slight cyanosis
-and clinical signs indicative for respiratory irritational effects
labored breathing, bradypnoe, dyspnoe, breathing sounds, nasal discharge, bloody nose, hypothermia

NOEL:809 mg/m³

On day 9 post exposure all animals had recovered

Applicant's summary and conclusion