Registration Dossier
Registration Dossier
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EC number: 200-543-5 | CAS number: 62-56-6
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline A-79.74 D
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- No details reported.
- Buffers:
- - pH 1.2: HCl, KCl
- pH 3,0: HCl/Citrate
- pH 7: Phopsphat/NaOH
- pH 9,0: Borate/NaOH
- all buffers at a concentration of 0.02 M
- all buffers were fumigated with nitrogen to avoid oxidative dagradation - Details on test conditions:
- No details reported.
- Number of replicates:
- No details reported
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- No data.
- Preliminary study:
- Preliminary study performed
- Test performance:
- Not applicable.
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- Not applicable.
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Other kinetic parameters:
- Thiourea does not hydrolyse.
- Details on results:
- Thiourea does not hydrolyse at pH 1.2, 3, 7, or 9.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Thiourea is not susceptible to hydrolysis at environmentally relevant pH.
- Executive summary:
The hydrolysis of thiourea was determined at pH 1.2, 3, 7, and 9 according to OECD Guideline A-79.74D at the concentration of maximum water solubility. The concentration of the parent substance in the test vessels was measured by means of UV spectroscopy. Under the conditions of the test no hydrolysis was observed.
The results are used in the assessment of the intirnsic properties of thiourea in a weight-of-evidence approach.
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline reported
- Principles of method if other than guideline:
- Not reported, secondary literature.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- No details reported, secondary literature.
- Buffers:
- No details reported, secondary literature.
- Details on test conditions:
- No details reported, secondary literature.
- Number of replicates:
- No details reported, secondary literature.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- No details reported, secondary literature.
- Preliminary study:
- No details reported, secondary literature.
- Test performance:
- No details reported, secondary literature.
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- No details reported, secondary literature.
- Key result
- pH:
- 4
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- No details reported, secondary literature.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Thiourea is stable to hydrolysis at pH 4, 7, and 9.
- Executive summary:
Thiourea is reported to be stable to hydrolysis at pH 4, 7, and 9.
Details on test method, analytical methods, and test duration are not available (secondary literature).
The results are used in the assessment of the intirnsic properties of thiourea in a weight-of-evidence approach.
Referenceopen allclose all
Description of key information
Thiourea is not susceptible to hydrolysis at environmentally relevant pH.
Key value for chemical safety assessment
Additional information
Two data sources are available that describe the hydrolysis of thiourea at different pH. Both data sources are of low reliability. However, as no other reliable standard data are available, and as both sources report the same result, the data are used in an weight-of-evidence approach:
Schmidt-Bleek et al. (1982) report that thiourea is stable to hydrolysis at pH 4, 7, and 9.
Details on test method, analytical methods, and test duration are not available (secondary literature).
Korte & Greim (1981) determined the hydrolysis of thiourea at pH 1.2, 3, 7, and 9 according to OECD Guideline A-79.74D at the concentration of maximum water solubility. The concentration of the parent substance in the test vessels was measured by means of UV spectroscopy. Under the conditions of the test no hydrolysis was observed.
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