Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-543-5 | CAS number: 62-56-6
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2011-09-12 to 2011-09-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- no
- Dissociating properties:
- not determined
- Conclusions:
- The pks-value is not determinable because Thiocarbamide forms no OH´ or H´ions.
- Executive summary:
The dissociation constant of Thiocarbamide was determined according to OECD guideline no. 112 with the titration method at 24°C.
The pks-value was not determinable because Thiocarbamide forms no OH´ or H´ions.
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline reported
- Principles of method if other than guideline:
- not reported because of handbook data
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- pKa:
- ca. -1
- Temp.:
- 25 °C
- Conclusions:
- The dissociation contant of thiourea at 25°C is pKa = -1
- Executive summary:
According the CRC Handbook of Chemistry and physics the dissociation contant of thiourea at 25°C is pKa = -1.
Referenceopen allclose all
The pks-value is not determinable because Thiocarbamide forms no OH´ or H´ions.
no detailled information on results -> handbook data
Description of key information
There are two different sources of information available which are used in a weight-of-evidence approach.
In the CRC Handbook of Chemistry and Physics the dissociation constant of thiourea at 25 °C is stated to be pKa = –1. Data on the determination dissociation constant according OECD guideline 112 of the sponsor showed that pka-value is not determinable because Thiourea forms no OH or H ions.
Key value for chemical safety assessment
- pKa at 20°C:
- -1
Additional information
According the CRC Handbook of Chemistry and physics the dissociation constant of thiourea at 25 °C is pKa = –1.
In another study provided by the sponsor the dissociation constant of Thiourea was determined according to OECD guideline no. 112 with the titration method at 24 °C. It was shown that the pka-value was not determinable because Thiourea forms no OH or H ions. This study is chosen as key value as an experimental result has a higher reliability than handbook data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
