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EC number: 200-543-5 | CAS number: 62-56-6
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2011-09-12 to 2011-09-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- no
- Dissociating properties:
- not determined
- Conclusions:
- The pks-value is not determinable because Thiocarbamide forms no OH´ or H´ions.
- Executive summary:
The dissociation constant of Thiocarbamide was determined according to OECD guideline no. 112 with the titration method at 24°C.
The pks-value was not determinable because Thiocarbamide forms no OH´ or H´ions.
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline reported
- Principles of method if other than guideline:
- not reported because of handbook data
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- pKa:
- ca. -1
- Temp.:
- 25 °C
- Conclusions:
- The dissociation contant of thiourea at 25°C is pKa = -1
- Executive summary:
According the CRC Handbook of Chemistry and physics the dissociation contant of thiourea at 25°C is pKa = -1.
Referenceopen allclose all
The pks-value is not determinable because Thiocarbamide forms no OH´ or H´ions.
no detailled information on results -> handbook data
Description of key information
There are two different sources of information available which are used in a weight-of-evidence approach.
In the CRC Handbook of Chemistry and Physics the dissociation constant of thiourea at 25 °C is stated to be pKa = –1. Data on the determination dissociation constant according OECD guideline 112 of the sponsor showed that pka-value is not determinable because Thiourea forms no OH or H ions.
Key value for chemical safety assessment
- pKa at 20°C:
- -1
Additional information
According the CRC Handbook of Chemistry and physics the dissociation constant of thiourea at 25 °C is pKa = –1.
In another study provided by the sponsor the dissociation constant of Thiourea was determined according to OECD guideline no. 112 with the titration method at 24 °C. It was shown that the pka-value was not determinable because Thiourea forms no OH or H ions. This study is chosen as key value as an experimental result has a higher reliability than handbook data.
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