Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Justification for selection of acute toxicity – oral endpoint
For both main components of the reation mass of Glycyl-L-glutamine and potassium chloride acute oral toxicity studies were conducted. In none of the studies an LD50 below 2000 mg/kg bw was recorded. As no study for the reaction mass of Glycyl-L-glutamine and potassium chloride is available, studies conducted with the two main components L-glycyl-L-glutamine and potassium chloride (such as this) were used for read-across in order to avoid unnecessary repitition of testing. As no synergistic or antagonistic effects from either of the main components are expected, the information derived from both main components is considered to be reliable for classification of the reation mass of Glycyl-L-glutamine and potassium chloride. Hence the reaction mass of Glycyl-L-glutamine and potassium chloride is not classified regarding acute oral toxicity.

Justification for classification or non-classification

For both main components of the reation mass of Glycyl-L-glutamine and potassium chloride acute oral toxicity studies were conducted. In none of the studies an LD50 below 2000 mg/kg bw was recorded. As no study for the reaction mass of Glycyl-L-glutamine and potassium chloride is available, studies conducted with the two main components L-glycyl-L-glutamine and potassium chloride (such as this) were used for read-across in order to avoid unnecessary repitition of testing. As no synergistic or antagonistic effects from either of the main components are expected, the information derived from both main components is considered to be reliable for classification of the reation mass of Glycyl-L-glutamine and potassium chloride. Hence the reaction mass of Glycyl-L-glutamine and potassium chloride is not classified regarding acute oral toxicity.