Registration Dossier

Administrative data

Endpoint:
skin sensitisation
Remarks:
other: In silico prediction
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
June, 2010
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In silico prediction using DEREK.
GLP compliance:
not specified
Type of study:
other: Derek evaluation

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

DEREK evaluation showed no alert for skin sensitization.

Applicant's summary and conclusion

Interpretation of results:
other: no alert
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Derek evaluation for the test item showed no alerts for skin sensitisation.
Executive summary:

The alert also includes coverage for hydrazone precursors of hydrazines.

The presence of a skin sensitisation structural alert within a molecule indicates the molecule has the potential to cause skin sensitisation.

Whether or not the molecule will be a skin sensitiser will also depend upon its percutaneos absorption.

Generally, small lipophilic molecules are more readily absorbed into the skin and are therefore more likely to cause sensitisation.