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Auto flammability

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Reference
Endpoint:
auto-ignition temperature (liquids)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar toxicological properties because
- they are manufactured from similar precursors under similar conditions
- they share structural similarities with common functional groups: the substances start with an acetylene group as core structure; geminal hydroxyl groups on the alpha carbon atoms; distal to the geminal hydroxyl groups is an isobutyl group (methyl isopropyl); the target substance 2,4,7,9-Tetramethyl-5-decyne-4,7-diol, ethoxylated (1.3) is further functionalised with ethylene oxide and has an ethoxylation degree of 1.3; the source substance 2,4,7,9-Tetramethyl-5-decyne-4,7-diol, ethoxylated (3.8) has an ethoxylation degree of 3.8
- they have similar physicochemical properties and thus, show a similar toxicokinetic behaviour
- they are expected to undergo similar metabolism: oxidation of the terminal methyl groups to result in alcohol, aldehyde and finally the corresponding acid

Therefore, read-across from the existing toxicity, ecotoxicity, environmental fate and physicochemical studies on the source substances is considered as an appropriate adaptation to the standard information requirements of REACH regulation.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
see “Justification for read-across” attached to IUCLID section 13

3. ANALOGUE APPROACH JUSTIFICATION
see “Justification for read-across” attached to IUCLID section 13

4. DATA MATRIX
see “Justification for read-across” attached to IUCLID section 13
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Reason / purpose:
read-across: supporting information
Auto-ignition temperature:
> 335 - < 338 °C
Atm. press.:
1 013 hPa
Conclusions:
The Autoignition Temperature of 2,4,7,9-Tetramethyl-5-decyne-4,7-diol, ethoxylated (3.8) is 335 - 338 °C. The autoignition temperature of 2,4,7,9-Tetramethyl-5-decyne-4,7-diol was determined to be 380 ± 10 °C. A value of 335°C will be used for chemical safety assessment.

Description of key information

Key value for chemical safety assessment

Autoflammability / Self-ignition temperature at 101 325 Pa:
335 °C

Additional information

No experimental data on autoignition temperature are available for the target substance 2,4,7,9-Tetramethyl-5-decyne-4,7-diol, ethoxylated (1.3). A justification for read-across is attached to iuclid section 13.

The Autoignition Temperature of 2,4,7,9-Tetramethyl-5-decyne-4,7-diol, ethoxylated (3.8) is 335 - 338 °C. The autoignition temperature of 2,4,7,9-Tetramethyl-5-decyne-4,7-diol was determined to be 380 ± 10 °C. A value of 335°C will be used for chemical safety assessment.