Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data for the structural analogon Texanol from a collection of data (OECD/SIDS 1994) with limited details.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1994
Report Date:
1974
Reference Type:
publication
Title:
Unnamed
Year:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test chemical was applied to the skin under an impervious plastic film for 24 h. Animals were observerd for 14 days following dosing. Melon Institute Protocol.
GLP compliance:
no
Remarks:
Test predates GLP.
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no further data

Administration / exposure

Type of coverage:
other: pervious
Duration of exposure:
24 h
Doses:
16 ml/kg (with density of 0.95 g/cm3: 15.2 g/kg bw)
No. of animals per sex per dose:
no details
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
>= 15 200 mg/kg bw

Any other information on results incl. tables

Dermal LD50 to rabbits was reported as >= 16 mL/kg (15.2 g/kg). No further details.

Applicant's summary and conclusion