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EC number: 215-716-0 | CAS number: 1345-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: no guideline available
- Deviations:
- not applicable
- GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- Bismuth citrate
- EC Number:
- 212-390-1
- EC Name:
- Bismuth citrate
- Cas Number:
- 813-93-4
- IUPAC Name:
- bismuth(3+) citrate
- Test material form:
- not specified
Constituent 1
Method
- Target gene:
- not applicable
Species / strain
- Species / strain / cell type:
- other: lymphocytes, hepatocytes, and erythrocytes
- Details on mammalian cell type (if applicable):
- no data
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 2.5, 5, 25, 50 and 250µM
- Vehicle / solvent:
- no data
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- no
- Positive controls:
- yes
- Remarks:
- MMAIII (Monomethylarsonous acid)
- Details on test system and experimental conditions:
- Human lymphocytes were exposed to, Bi-Cit in a concentration runge from 2.5 to 250 ,uM for I h). Following incubation, cells were washed twice
and resuspended in 5 mL of McCoy's 5A medium. For the evaluation of first post-treatment metaphases with CA, cells were prelubeled with
20 ,uM BrdU (Serva, Heidelberg, Gennany). Thereafter, cells were cultivated for an additional 44 h for the examination of CA. CeII growth was stopped by treatment of lymphocytes with 0.08 ,ug/mL colcemid solution (Ciba.Basel, Switzerland) for a further 4 h. Metaphases were stained with Hoechst-Giemsa solution (Bisbenzimid, Merck, Germany) as described by Hill and Wolff. At least 100 uniformly stained first post-treatment metaphases were analyzed for CA. All experiments were performed in duplicate. The trivalent monomethylarsenic compound, monomethylarsonous acid [MMA(lll), 0.5µM, I und 24 h exposure],was run alongside as a positive control . The x square test was used for the statistical analysis of CA. - Evaluation criteria:
- no data
- Statistics:
- The x square test was used for the statistical analysis of CA.
Results and discussion
Test results
- Species / strain:
- other: lymphocytes, hepatocytes, and erythrocytes
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- A chromosome aberration test of dibismuth trisulfide is not available. Consequently, read-across from the inorganic bismuth citrate was performed. Bismuth citrate did not induce chromosome aberrations up to the highest tested concentration of 250 µM. Bismuth citrate did not show any genotoxic effect. In contrast to inorganic bismuth compounds, organic bismuth compounds might show genotoxic potential. Therefore, dibismuth trisulfide was considered to be non-genotoxic in this test system.
- Executive summary:
A chromosome aberration test of dibismuth trisulfide is not available. Consequently, read-across from the inorganic nismuth citrate was performed. Bismuth citrate did not induce chromosome aberrations up to the highest tested concentration of 250 µM. Bismuth citrate did not show any genotoxic effect. In contrast to inorganic bismuth compounds, organic bismuth compounds might show genotoxic potential. Therefore, dibismuth trisulfide was considered to be non-genotoxic in this test system.
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