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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: According to international guideline(s), GLP-compliant, performed in recognized contract research organization, no restrictions, fully adequate for assessment.
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
< 1
Temp.:
25 °C
Remarks on result:
other: Retention times of the test material were lower than the retention time of the first reference substance

The retention times of the test material were 2.30 min, 2.49 min and 2.63 min which are lower than the retention time of the first reference substance (acetanilide, 2.96 min) therefore the log Pow is < 1.0.

Conclusions:
For the test material WS400402 log Pow is <1.0.

Description of key information

Commission Regulation (EC) No 440/2008, Method A.8; OECD guideline No. 117

Method: HPLC method

Results: The retention times of the test material were lower than the retention time of the first reference substance (acetanilide, 2.96 min) therefore the log Pow is <1.0 at 25 °C.

Key value for chemical safety assessment

Additional information