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2-Amino-2 -methylpropanol meets the criteria of ready biodegradability in an OECD 301F Manometric Respirometry test (tox study TERC 2010), with 89% biodegradation in 28 days based on oxygen consumption. In supporting studies (Harlan 2009), biodegradation of the test compound after 28 days reached 45% in another OECD 301F test and 40% in an OECD 301D Closed Bottle Test.


In OECD 301F study, the test and reference substances contain nitrogen, ThODNH3 is calculated from the molecular formula of the test and reference substance, and reflects the theoretical amount of oxygen required for complete oxidation of the substances to CO2, water, and ammonia.

Whereas “Harlan’s” study calculated the Oxygen consumption by ThOD (No3). 

As per  OECD guideline: The corrected value for oxygen consumption due to C oxidation is then compared with ThOD NH3, as calculated in Annex IV

If we desire the ThOD to approximate the COD value should calculate without Nitrification. COD measurement does not consider Nitogenous Oxygen demand which manifests after 6th day (manifests slowly).

  1. TERC study calculated degradation biodegradation based on O2 consumption, CO2 production and DOC removal and reached 119.8%, 91.6% and 98.6% in 28 days.  

  2. Harlan’s study calculated degradation based on measurement of daily oxygen consumption values (45% degradation) and Dissolved Organic Carbon (94% degradation) analysis on Days 0 to 28. 

Based on the above rationale, the results from the TERC study is a better representation of the biodegradation potential of AMP.