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EC number: 215-542-5 | CAS number: 1330-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Experimental toxicokinetic study was not available on isodecyl acrylate.
Based on the chemical and physical data, a low absorption of isodecyl acrylate is expected after oral route, dermal route or inhalation.
Key value for chemical safety assessment
Additional information
Experimental toxicokinetic study was not available on isodecyl acrylate.
Chemical and physical properties of isodecyl acrylate :
- Molecular weight : 212, 33 g/mol
-Vapour pressure: 3,61 Pa (20°C)
-Water solubility: 1,34 mg/L
-Log Kow: 5.55
Information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, according to the REACH guidance document R7.C (2012).
ABSORPTION
Based on the physicochemical characteristics of isodecyl acrylate, a log Kow higher than 5 and a low water solubility, a low oral absorption is expected. This assumption of a low oral absorption is confirmed by the data acute oral toxicity (LD50 = 9486 mg/kg bw in rats).
Dermal absorption of isodecyl acrylate is expected to be slowed due to binding to skin of the acrylate group and the low solubility water. This is supported by the low toxicity observed in acute dermal testing (LD50 > 3150 mg/kg bw). However, isodecyl acrylate is a moderate skin sensitizer based on the LLNA. Finally, a dermal absorption of isodecyl acrylate is expected to be low.
According to the value of the vapour pressure (3,61 Pa at 20°C), isodecyl acrylate is considered to be slightly volatile. In the data acute toxicity, no death and no clinical signs were observed at the dose of 0,333 mg/L (maximum attainable concentration). No absorption by inhalation of isodecyl acrylate is expected at the maximum attainable concentration due to the low values of vapour pressure and water solubility.
DISTRIBUTION/ METABOLISM/ EXCRETION
As a small molecule a wide distribution of isodecyl acrylate is expected.
No specific information was found on metabolism of isodecyl acrylate.
However, according to the hydrolysis tests performed on isodecyl acrylate, the substance is stable at the pH 4 and 7. Therefore no hydrolysis is expected in the rodent (stomach pH between 3 and 5).
But at the pH 1 and 9, isodecyl acrylate is not stable. Evidence from other types of acrylates suggests that hydrolysis of the ester bond is likely to occur, producing acrylic acid and the corresponding alcohol, which are subsequently metabolised through normal metabolic routes.
The major routes of excretion for both substances from the systemic circulation are the urine (due to the low molecular weight) and the exhaled air (of the hydrolysis products).
Bibliographic sources
De Bethizy et al.(1987). Fund. Appl. Tox. 8: 549-561
Deisinger PJ, Boatman RJ and Guest D (1994.Xenobiotica 24, 429-440
Frederick et al. (1992). Toxicol.Appl. Pharm. 114: 246-260
Frederick et al. (1994). Toxicol. Lett. 70: 49 -56
Ghanayem et al. (1987). Fundam. Appl. Toxicol. 9: 389-397
Linhart et al.(1994). Xenobiotica 24: 1043-1052
McCarthy TJ and Witz G (1997). Toxicology 116, 153-158
Roos K., Bachelorthesis, 2014
Silver and Murphy (1981). Toxicol.Appl. Pharmacol. 57: 208-219
Vodicka et al. (1990). Toxicology 65: 209-22
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