Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-124-0 | CAS number: 133-91-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 3.1.0.21 prediction for LD50 read across evaluation for CAS 133-91-5
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 013
- Bibliographic source:
- QSAR Toolbox version 3.1
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,5-diiodosalicylic acid
- EC Number:
- 205-124-0
- EC Name:
- 3,5-diiodosalicylic acid
- Cas Number:
- 133-91-5
- Molecular formula:
- C7H4I2O3
- IUPAC Name:
- 2-hydroxy-3,5-diiodobenzoic acid
- Details on test material:
- - Name of test material: 3,5-diiodosalicylic acid
- Molecular formula: C7H4I2O3
- Molecular weight: 389.91
- Substance type: Organic
- Physical state: Solid
- Smiles: C(=O)(O)c1c(O)c(I)cc(I)c1
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ICR;B6C3F1;ddY;no data;Swiss
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral: gavage;oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 410.333 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and ("b" and ( not "c") ) ) and ("d" and "e" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Phenols (Acute toxicity) by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 16 - Oxygen O AND Group 17 - Halogens F,Cl,Br,I,At AND Group 17 - Halogens I by Chemical elements
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Group 15 - Nitrogen N OR Group 17 - Halogens Br OR Group 17 - Halogens Cl by Chemical elements
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is >= 1.33
Domain logical expression index: "e"
Parametric boundary:The target chemical should have a value of log Kow which is <= 5.03
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Acute oral toxicity (LD50) value of 3,5-diiodosalicylic acid on Rat on the basis of mortality effect was estimated to be 2410.33 mg/kg bw. This value indicates that the substance 3,5-diiodosalicylic acid is not toxic to Rat by oral route.
- Executive summary:
The Acute oral toxicity (LD50) value of 3,5-diiodosalicylic acid on Rat on the basis of mortality effect was estimated to be 2410.33 mg/kg bw. This value indicates that the substance 3,5-diiodosalicylic acid is not toxic to Rat by oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
