Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Short-term toxicity to fish :

No. of predictions done for short term fish toxicity endpoints having Klimish rating 2

The summary of the results are presented below:

 

Sr. No

Endpoint name

Value

Effect

Species

Source

1

LC50

6.449672699 mg/l

Mortality

Oryzias latipes

SSS QSAR

2

LC50

5.768873215 mg/l

Mortality

Pimephales promelas

SSS QSAR

3

LC50

3.296432972 mg/L

Mortality

Cyprinodon variegatus

SSS QSAR

4

LC50

7.42 mg/L

Mortality

Fish

ECOSAR

5

LC50

10 mg/L

Mortality

Ptychocheilus oregonensis : Northern Squawfish

ECOTOX

 

After comparing the short term toxicity values from predictions done in QSAR rtoolbox 3.1 & estimated data from ECOSAR & ECOTOX. it was estimated values varies from 3.296432972 to 10 mg/l . But the BCF value of 3,5-diiodosalicylic acid reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification. It is concluded that 3,5-diiodosalicylic acid does not exhibit short term toxicity to fish.

 

Short-term toxicity to aquatic invertebrates :

No. of predictions done for short term Aquatic invertebrate endpoints having Klimish rating 2

The summary of the results are presented below:

 

Sr. No

Endpoint name

Value

Effect

Species

Source

1

EC50

7.907 mg/L

Mobility

Daphnia magna

SSS QSAR

2

LC50

7.045 mg/L

Mortality

Daphnia magna

ECOSAR Version 1.10

3

EC50

1.889201522 mg/L

Intoxication

Daphnia magna

SSS QSAR

 

After comparing the short term toxicity values from predictions & estimated calculation. It was found to be varies from 1.889201522 to 7.097 mg/l. But the BCF value of 3,5-diiodosalicylic acid reported was not >= 500 as well as the substance was found to be rapidly degradable Thus considering only the value from CLP Criteria for aquatic classification of the substance , it is concluded that 3,5-diiodosalicylic acid does not exhibit short term toxicity to Aquatic invertebrate (Daphnia magna).

 

Toxicity to aquatic algae and cyanobacteria:-

No. of predictions done for short termtoxicity to algae and cynobacteriaendpoints having Klimish rating 2.

The summary of the results are presented below:

 

Sr. No

Endpoint name

Value

Effect

Species

Source

1

EC50

22.351 mg/l

Growth rate

Selenastrum capricornutum (new name: Pseudokirchnerella subca

SSS QSAR

2

EC50

25.221 mg/L

-- --- ---

Green Algae

ECOSAR Version 1.10

3

EC50

3.954859257 mg/L

Growth rate

Selenastrum capricornutum (new name: Pseudokirchne

SSS QSAR

4

EC50

7.045009136 mg/L

Growth rate

Pseudokirchneriella subcapitata

SSS QSAR

 

After comparing the Toxicity to algae and cynobacteria values from QSAR 3.1 predictions & estimated calculations. it was found to be varies from 3.954 to 25.221 mg/L The BCF value of 3, 5-diiodosalicylic acid reported was not >= 500 as well as the substance were found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.