Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Very old studies. No guidelines followed. Severe deficiencies to todays standards. Only secondary literatur available.

Data source

Reference
Reference Type:
secondary source
Title:
BUA Stoffbericht 55: Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
BUA Beratergremium für umweltrelevante Altstoffe
Year:
1990
Bibliographic source:
Verlag Chemie Weinheim 1991

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloro-o-toluidine
EC Number:
201-756-6
EC Name:
3-chloro-o-toluidine
Cas Number:
87-60-5
Molecular formula:
C7H8ClN
IUPAC Name:
3-chloro-2-methylaniline

Test animals

Species:
cat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
other: Oil, not further specified and no vehicle
Doses:
119 + 298 mg/kg

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: not specified
Effect level:
119 mg/kg bw
Remarks on result:
other: acute signs of intoxication but animals survived
Sex:
not specified
Dose descriptor:
other: not specified
Effect level:
298 mg/kg bw
Remarks on result:
other: Animal died within 23 h.

Any other information on results incl. tables

The intoxication symptoms seem to be predominantly caused by cyanosis.

Applicant's summary and conclusion