Registration Dossier

Physical & Chemical properties

Water solubility

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Description of key information

The water solubility of the registered substance was found to be >25% via a preliminary visual water solubility assessment at pH 7 and ambient temperature (22.4°C). A further visual assessment found a water solubility of >50% (>500 g/l). 

Key value for chemical safety assessment

Water solubility:
500 g/L
at the temperature of:
22.4 °C

Additional information

The water solubility of the registered substance was detemined in accordance with a method similar to the EU Testing Method A.6. as part of a study of the behaviour of the test substance in water. The water solubility of the test substance was found to be >25% via a preliminary visual water solubility assessment at pH 7 and ambient temperature (22.4°C). A further visual assessment found a water solubility of >50% (>500 g/l). In addition, an equivalent study conducted on the structurally similar substance 6 -[(p-Tosyl)amino]hexanoic acid, compound with 2,2',2''-nitrilotriethanol (1:1) (Tosyl salt) gave the same water solubility of 25% after an initial visual assessment, and 50% after a further visual assessment. Read-across between the registered substance and the test substance (Tosyl salt) is considered justified owing to the structural similarity of the two substances. Both are salts of a carboxylic acid and triethanolamine. The acid components are structural isomers and differ only in the position of a single methyl group in the N-methyl salt. This is not expected to change the behavior or properties of the substances, and both substances have shown similarity in the results of other physical endpoints such as relative density, partition coefficient and surface tension.