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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well described study based on BASF internal standards

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report Date:
1984

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standards
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance used in the study report: Borfluorid-Ethyletherat

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals and environmental conditions:
Mean animal body weight: 2.9 kg. The animals were offered a laboratory animal standard diet (Ssniff) and water ad libitum.

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
Patch test, soaked with the undiluted test substance
Duration of treatment / exposure:
1 min, 5 min, 15 min, 20 hours
Observation period:
8 days
Number of animals:
4
Details on study design:
After the 5- or 15-min application, only the treated skin areas were rinsed with undiluted Lutrol 9 and thereafter with a 50% aqueous Lutrol solution.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 15 min
Score:
4
Max. score:
4
Reversibility:
not reversible
Irritant / corrosive response data:
24 hours after the 1-min application, the skin was partly reddened in patches, after the 5-min. application slight necroses occurred in parts. In addition, 24 hours after the applications lasting 15 minutes and 20 hours, the skin was necrotic throughout and corroded down to the muscle. Due to the strong corrosive effects, two animals had to be sacrificed 24 hours and three days after application, respectively.

Any other information on results incl. tables

Table of effects

 Time of incubation  Effects after 24 h  additional information
 1 min  R+  
5 min  N+  
 15 min  N+++ (muscle visible) Killing of the animals for human reasons
 20 h  N+++ (necrosis includes muscle) Killing of the animals for human reasons
 20 h (ear)  N+++; E+++  

N = necrosis

R = reddening

E = edema

(+) = no clear effects

+ = slight

++ = strong

+++ = very strong

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information