Alcohols, C16-17-branched and linear

Toxicity to aquatic algae and cyanobacteria

Additional information

No data are available for the growth inhibition to aquatic plants with Alcohols, C16-17, branched and linear. The growth inhibition to aquatic plants has been estimated by read-across and expert judgement to be above the limit of solubility (LoS). Alcohols, C16-17, branched and linear is made up of C16 and 17 branched and linear alcohols. Across the alcohols category it is possible to see from Table 1 that no growth inhibition term toxicity is visible at the LoS for alcohols C14.
From Table 2, it is possible to see that the EC(EL)50 and LC(LL)50 values are not achieved for Alcohols,C14-15, branched and linear. Since the water solubility decreases with increasing chain length, also for UVCB alcohols in table 2, it is safe and reliable to predict that EC(EL)50 and LC(LL)50 would not be achieved at the LoS.

 

Table 1. Estimated acute toxicity to algae for essentially pure commercial products (using expert judgment where no data are available).

 

CAS #	Comment^1	Water solubility (mg/L)	Fish LC50 (mg/L)^2	Invert EC50 (mg/L)^2	Algae EC50 (mg/L)^2
111-27-3	6	5900 at 20°C	97	201	80
111-70-6	7¿ SUPPORTING	1313 at 20°C	38	82
111-87-5	8	551 at 25°C	13	20	6.5 (biomass)-14 (growth)
143-08-8	9	128 at 20 °C	5.5	25	1.0-10 (r-a)
112-30-1	10	39.5	2.3	3.1	1.0-10 (r-a)
112-42-5	11	8.0 at 20°C	1.0	0.8	0.1-1.0 (r-a)
112-53-8	12	1.93 at 20°C	1.0	0.77	0.62 (biomass) 2.6 (growth)
112-70-9	13 ¿ SUPPORTING	0.38 at 20°C	>0.33	No effects expected at LoS^3	0.1-1.0 (r-a)
112-72-1	14	0.191 at 25°C	LC50 not reached >LoS	4 (>LoS)	EC50 not reached >LoS
629-76-5	15	0.102 at 25°C	No effects expected at LoS^3	No effects expected at LoS^3	>0.047 (r-a C15 branched)
36653-82-4	16	0.013 at 25°C	LC50 not reached >LoS	No effects expected at LoS^3	EC50 not reached >LoS
112-92-5	18	0.0011 at 25°C	LC50 not reached	EC50 not reached >LoS	EC50 not reached >LoS
143-28-2	18 (unsaturated)	0.009 mg/L [estimated]	No effects expected at LoS^4	No effects expected at LoS^4	No effects expected at LoS (r-a)
629-96-9	20	Ca. 0.001 mg/L [estimated]	No effects expected at LoS^3	No effects expected at LoS^3	No effects expected at LoS (r-a)
661-19-8	22	Ca. 0.001 mg/L [estimated]	LC50 not reached >LoS	No effects expected at LoS^3	No effects expected at LoS (r-a)
506-51-4	24	Ca. 0.001 mg/L [estimated]	LC50 not reached >LoS (r-a from C22)	No effects expected at LoS^3	No effects expected at LoS (r-a)

 

Notes:

1 ¿ compositional Types are discussed in CSR

2 ¿ LoS = Limit of solubility.

3 ¿ estimated using QSAR (see CSR)

4 ¿ estimated using QSAR method and read-across from C16-18 and 18 unsaturated.

n/a ¿ not available

Unless specified read-across has occurred from the same substance data and different taxonomic groups.

 

Table 2. Estimated acute toxicity to algae for multi-constituent alcohols commercial products (using expert judgment where no data are available).

 

MCS #	Comment^1	Water solubility (mg/L)	Fish LC50 (mg/L)^2	Invert EC50 (mg/L)^2	Algae EC50 (mg/L)^2
1	Alcohols, C7-9-linear and branched	510 mg/l at a loading rate of 1000 mg/l [estimated]	0.7-0.8	5.9	3.1
2	Alcohols, C9-11-linear and branched	44 mg/l at a loading rate of 1000 mg/l. [estimate]	6.3-10	7	2.7
12	Nonanolbranched	121 mg/L [estimated]	5.5 (r-a from C9)	25 (r-a from C9)	1.0-10 (r-a)
	Decanol, branched	38.9 mg/L	2.3 (r-a from C10)	3.1 (r-a from C10)	1.0-10 (r-a)
	Decanol, branched and linear	26.17 mg/L at 20°C	2.3 (r-a from C10)	3.1 (r-a from C10)	1.0-10 (r-a)
10	Undecanol, linear and branched	6.3 at 25°C	1.0 (r-a from C11)	0.8 (r-a from C11)	1.0-10 (r-a)
4	Alcohols, C12-13, branched and linear	2.9-3.1 mg/L at 20°C	2.8	15 WAFs (>LoS)	ErC50 0.44 EbC50 0.23 NOEC 0.058
5	Alcohols, C12-15, branched and linear	0.8 mg/L	>LoS	<1 WAFs	ErL50 0.085-0.097 EbL50 0.039-0.045 NOEL 0.003
3	Alcohols, C12-13, branched and linear	2.4 mg/L at 25^oC	4.0-10 as WAFs (>LoS)	0.23 as WAFs	ErL50 0.23 EbL50 0.084 NOEL 0.03
6/7	Alcohols, C14-15, branched and linear	0.7 mg/l at 20°C and 0.15 mg/l at a loading rate of 1000 mg/l. [estimated]	>500 (n) >0.7 (n)   (both >LoS)	0.13-0.29	ErL50 22-46 EbL50 22-46 NOEL 4.6
8/9	Alcohols, C16-17, branched and linear	Ca. 0.1-0.4 mg/L (r-a from C16-17, monobranched)	>LoS (r-a from C16)	>LoS (r-a from C16)	>LoS (r-a from C16)

 

Notes:

1 - compositional Types are discussed in CSR

2 - LoS = Limit of solubility.

3 - estimated using QSAR (see CSR)

4 - estimated using QSAR method and read-across from C16-18 and 18 unsaturated.

n/a - not available

WAFs - water accommodated fractions

Unless specified read-across has occurred from the same substance data and different taxonomic groups.