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Diss Factsheets

Administrative data

Description of key information

No studies are available on the registered substance. The potential for irritancy was evaluated on the basis of the data available on propane-1 -thiol and propane-2 -thiol. Therefore, the registered substance is not considered to be irritating to skin, eyes and respiratory tract.

 

Skin irritation

Study on propane-2 -thiol

As prescribed in U.S. DOT guideline 49 CFR 173.240, one -half ml of undiluted propane-2-thiol was applied to the intact skin site under standard gauze patches of six albino rabbits (Latven, 1977). The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, moderate erythema (score 2) was present at all of the treated sites, this dissipated completely overnight. No other signs of skin irritation were discernible. Propane-2-thiol is almost slightly irritating to the skin.

 

Study on propane-1-thiol

As prescribed in 49 CFR 173.240, one -half ml of undiluted propane-1-thiol was applied to the intact skin site under standard gauze patches of six albino rabbits (Latven, 1976). The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, no effects were discernible at any of the treated skin sites. Propane-1-thiol is not irritating to the skin.

 

Eye irritation

Study on propane-2-thiol

In a preguideline study (Latven, 1977), a 0.1 ml dose of propane-2-thiol was instilled into one eye of six rabbits. Irritation was scored at 10 min and 1, 2, 3, 4, 24, 48 and 72 hours. The only effect was conjunctival inflammation with or without chemosis. Neither the cornea nor the iris was effected. The responses recovered within 24 hours in five of six rabbits while the sixth animal recovered within 48 hours. Propane-2-thiol is a minimal eye irritant.

 

Study on propane-1-thiol

In a preguideline study (Latven, 1958), an unreported amount of propane-1-thiol was instilled into the conjunctival sac of the eyes of three rabbits. Eyes were exposed for 60 seconds followed by wiping with a cotton swab, and exposed for 10 seconds followed by flushing the eyes with saline. Animals then were observed for 7 days. Irritation was scored by the method of Draize. Irritation from exposure was noted but effects were fully reversible by 2 days. The study authors reported a Draize score of 13 out of a possible 30, with full recovery at 2 days. Propane-1-thiol is slightly irritating to the eyes.

 

Respiratory irritation

Propane-2-thiol is not a respiratory tract irritant in mice after an acute inhalation exposure of 1 min up to the concentration of 36.07 mg/l (Pence, 1983b). In 4-hour acute inhalation toxicity studies (Pence, 1983a; Hardy and, 1987a and 1987b), signs of an irritant effect, including partial closing of eyes, reduced respiratory rate, abnormal respiratory movements were observed during exposure to high concentrations.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Referenceopen allclose all

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with national standard methods with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: US DoT guideline no. 49 CFR 173.240
GLP compliance:
no
Species:
rabbit
Strain:
other: Albino
Details on test animals or test system and environmental conditions:
No detail available
Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
4 hours
Observation period:
up to 72 hours
Number of animals:
6
Irritation parameter:
erythema score
Basis:
animal: 1 to 6
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal: 1 to 6
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
When exposures were terminated, moderate erythema (score 2) was present at all of the treated sites, this dissipated completely overnight. No other signs of skin irritation were discernible.
Other effects:
Initial skin contact evoked a mild pain reaction
Interpretation of results:
GHS criteria not met
Executive summary:

As prescribed in 49 CFR 173.240, one -half ml of undiluted propane-2 -thiol was applied to the intact skin site under standard gauze patches of six albino rabbits. The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, moderate erythema (score 2) was present at all of the treated sites, this dissipated completely overnight. No other signs of skin irritation were discernible. Propane-2 -thiol is almost slightly irritating to skin.

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable without restriction because it was conducted according to or similar to guideline.
Qualifier:
according to guideline
Guideline:
other: US DoT guideline no. 49 CFR 173.240
GLP compliance:
not specified
Species:
rabbit
Strain:
other: Albino
Details on test animals or test system and environmental conditions:
No data
Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
4 hours
Observation period:
up to 72 hours
Number of animals:
6
Irritation parameter:
erythema score
Basis:
other: all animals
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
other: all animals
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
No effects were discernible at any of the treated skin sites.
Interpretation of results:
GHS criteria not met
Executive summary:

As prescribed in 49 CFR 173.240, one -half ml of undiluted propane-1-thiol was applied to the intact skin site under standard gauze patches of six albino rabbits. The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, no effects were discernible at any of the treated skin sites.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records

Referenceopen allclose all

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with national standard methods with acceptable restrictions
Qualifier:
no guideline followed
Principles of method if other than guideline:
Draize method
GLP compliance:
no
Species:
rabbit
Strain:
other: Albino
Details on test animals or tissues and environmental conditions:
No detail available
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
Not rinsed
Observation period (in vivo):
10 min and 1, 2, 3, 4, 24, 48 and 72 hours
Number of animals or in vitro replicates:
6
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

SCORING SYSTEM: Draize scale

TOOL USED TO ASSESS SCORE: No data
Irritation parameter:
conjunctivae score
Basis:
animal: 1 to 5
Time point:
24/48/72 h
Score:
0
Max. score:
3
Irritation parameter:
conjunctivae score
Basis:
animal #6
Time point:
24/48/72 h
Score:
0.66
Max. score:
3
Reversibility:
fully reversible within: 72 h
Irritation parameter:
chemosis score
Basis:
animal: 1 to 6
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
cornea opacity score
Basis:
animal: 1 to 6
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
animal: 1 to 6
Time point:
24/48/72 h
Score:
0
Max. score:
2
Irritant / corrosive response data:
The only effec was conjunctival inflammation with or without chemosis. Neither the cornea nor the iris was effected
Interpretation of results:
GHS criteria not met
Executive summary:

In a preguideline study, a 0.1 ml dose of iso-propyl mercaptan was instilled into one eye of six rabbits. Irritation was scored at 10 min and 1, 2, 3, 4, 24, 48 and 72 hours. The only effect was conjunctival inflammation with or without chemosis. Neither the cornea nor the iris was effected. The responses recovered within 24 hours in five of six rabbits while the sixth animal recovered within 48 hours. Iso-propyl mercaptan is a slight eye irritant.

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1958
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reporting of the study methods and results was limited.
Principles of method if other than guideline:
Draize test
GLP compliance:
no
Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data reported
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
No data
Duration of treatment / exposure:
60 seconds, and 10 seconds followed by saline flush
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
3 animals
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): cotton swab or flushed with saline

SCORING SYSTEM:
Draize scoring method

TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein
No data reported
Irritation parameter:
other: Maximal corneal irritation score
Basis:
animal: 1 to 3
Time point:
24 h
Score:
ca. 13
Max. score:
30
Reversibility:
fully reversible within: 2 days
Irritation parameter:
cornea opacity score
Basis:
animal: all
Time point:
24/48/72 h
Remarks on result:
other: not available
Irritation parameter:
conjunctivae score
Basis:
animal: all
Time point:
24/48/72 h
Remarks on result:
other: not available
Irritation parameter:
chemosis score
Basis:
animal: all
Time point:
24/48/72 h
Remarks on result:
other: not available
Irritation parameter:
iris score
Basis:
animal: all
Time point:
24/48/72 h
Remarks on result:
other: not available
Other effects:
No data reported
Interpretation of results:
GHS criteria not met
Conclusions:
Irritation from exposure was noted but effects were fully reversible by 2 days. The study authors reported a Draize score of 13 out of a possible 30, with full recovery at 2 days.
Executive summary:

In a primary eye irritation study, an unreported amount of propane-1 -thiol was instilled into the conjunctival sac of the eyes of three rabbits. Eyes were exposed for 60 seconds followed by wiping with a cotton swab, and exposed for 10 seconds followed by flushing the eyes with saline. Animals then were observed for 7 days. Irritation was scored by the method of Draize.

Irritation from exposure was noted but effects were fully reversible by 2 days. The study authors reported a Draize score of 13 out of a possible 30, with full recovery at 2 days.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for classification or non-classification

No classification is warranted according to CLP criteria.