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EC number: 202-844-7 | CAS number: 100-36-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- According to BASF-internal standard, see details in remarks on material and methods.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-aminoethyldiethylamine
- EC Number:
- 202-844-7
- EC Name:
- 2-aminoethyldiethylamine
- Cas Number:
- 100-36-7
- Molecular formula:
- C6H16N2
- IUPAC Name:
- N1,N1-Diethyl-1,2-ethanediamine
- Details on test material:
- Name of the test substance used in the study report: N,N-Diaethyl-aethylendiamin
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: he adjacent eye served as saline control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 50 µL - Duration of treatment / exposure:
- Single application
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3 hours on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. The report describes findings after 1 and 24 hours and at the end of the observation period.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corrosion
- Basis:
- mean
- Time point:
- other: within few minutes
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: Reaction observed shortly after instillation.
Any other information on results incl. tables
Already after a few minutes of the test substance instillation, corrosion of the eyes was observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Executive summary:
In this acute eye irritation/corrosion study (BASF, 1969), the eyes of 2 Vienna White rabbits were exposed by application of 50 µL undiluted test substance into the conjunctival sac. The animals were observed after 10 min, 1 and 3 hours on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours. Overall, the treatment caused corrosion of the eye mucous membranes within 1 hour.Thus, the test substance was graded as corrosive under the conditions of this study. This study is classified as acceptable. It satisfies the requirements of OECD test guideline 405.
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