Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-844-7 | CAS number: 100-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-aminoethyldiethylamine
- EC Number:
- 202-844-7
- EC Name:
- 2-aminoethyldiethylamine
- Cas Number:
- 100-36-7
- Molecular formula:
- C6H16N2
- IUPAC Name:
- N1,N1-Diethyl-1,2-ethanediamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: MUS RATTUS, Brunnthal, Germany (SPF breeding)
- Age at study initiation: Not reported
- Weight at study initiation: 185 +/- 15 g
- Fasting period before study: Not reported
- Housing: Not reported
- Diet: Herilan MRH of H. EGGERSMANN KG, Rinteln/Weser, Germany, ad libitum
- Water: Tap water, ad libitum
- Acclimation period: Not reported
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Whole-body inhalation system (groups of 5 animals are placed in wire cages which are located in a glass-steel inhalation chamber)
- Exposure chamber volume: V= 200 L
- Method of holding animals in test chamber: Wire cages
- Source and rate of air: Generator system: Continuous infusion pump UNITA I (BRAUN, Germany)
- Method of conditioning air: By means of a continuous infusion pump, constant amounts of the test substance were supplied to an evaporator heated to 75°C. The vapours that were formed were mixed with a flow of fresh air and passed into the inhalation chamber.
- System of generating particulates/aerosols: Glass evaporator with thermostat (BASF)
- Method of particle size determination: No further data
- Treatment of exhaust air: No further data
- Temperature, humidity, pressure in air chamber: No further data
TEST ATMOSPHERE
- Brief description of analytical method used: Gaschromatography
- Samples taken from breathing zone: yes (4 mm probe)
- Pressure ratio: By means of an exhaust air system, the pressure ratios in the inhalation system were adjusted in such a way that there was a pressure slightly below the atmospheric pressure (negative pressure). The inhalation mixture was offered to the animals for inhalation for 4 hours.
VEHICLE
- Composition of vehicle: fresh air
- Concentration of test material in vehicle: technical maximal attainable concentration
- Justification of choice of vehicle: volatility of test substance
TEST ATMOSPHERE
- Particle size distribution: No data available
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): No data available - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gaschromatography (HP5040 A)
- Duration of exposure:
- 4 h
- Concentrations:
- 2.35; 2.5 mg/L (analytical concentrations)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: technical maximal attainable concentration
- Mortality:
- 1/10 (2.5 mg/L) after 1 day
0/10 (2.35 mg/L) - Clinical signs:
- other: Intermittently resp. irregular breathing, eyelid closure, clotty fur, long-legged and staggering gait, ruffled fur. After 4 resp. 5 days no findings.
- Body weight:
- 2.5 mg/L: mean body weight before study start 177.5 g, after 14 days 223.5 g
2.35 mg/L: mean body weight before study start 177.5 g, after 14 days 233.5 g - Gross pathology:
- Sacrificed animals: heart: dilatation of the atrium, acute congestive hyperemia; liver: slightly pale-grey
Animal that died: nothing abnormal detected. - Other findings:
- Dosing group 1:
Nominal concentration: 9.78 mg/L, analytical conc. 2.5 mg/L
Dosing group 2:
Nominal concentration: 2.35 mg/L, analytical conc. 9.07 mg/L
Applicant's summary and conclusion
- Executive summary:
In an acute inhalation study according to BASF-internal standard (BASF1980), the test substance was tested in 20 rats (10 animals per sex) at the technical maximal attainable concentration. The analytical concentrations were 2.35 and 2.5 mg/L. As clinical signs irregular breathing, eyelid closure, clotty fur, long-legged and staggering gait, and ruffled fur were observed up to max. 5 days after study beginning.One animal died after 1 day (2.5 mg/L), necropsy revealed no irregular findings. In sacrificed animals, observations were: heart: dilatation of the atrium, acute congestive hyperemia; liver: slightly pale-grey.The LC50 (4h) was deemed as > 2.5 mg/L (> 530 ppm).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
