Registration Dossier
Registration Dossier
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EC number: 202-844-7 | CAS number: 100-36-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No data on toxicokinetics, metabolism and distribution are available for 2-aminoethyldiethylamine. Based on the available toxicological studies and the physico-chemical properties, particularly water solubility and octanol-water partition coefficient, absorption via oral, inhalative and dermal route a respective assessment is possible. The test substance is expected to be well absorbed by the respiratory and gastro-intestinal tracts and through the skin.The target test substance is assumed to be widely distributed and comprehensively metabolized. If not excreted unchanged, excretion of the metabolites may occur predominantly via the urine. The test substance is not expected to accumulate and there is no evidence for a (sex-)specific toxic effect.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The assessment of the toxicokinetics of
2-aminoethyldiethylamine is based primary on the available toxicological
data and the physicochemical properties as suggested by the REACH
Guidance Chapter R.7c.
Molecular weight: 116.2 g/mol
Water solubility: miscible
Partition coefficient log Kow = 0.1 at 25 °C
ABSORPTION
Oral route
According to the REACH Guidance, the physicochemical characteristics of
2-aminoethyldiethylamine and the molecular mass are in a range
suggestive of absorption as such from the gastro-intestinal tract
subsequent to oral ingestion. This assumption of oral absorption is
supported by the mortality observed in the acute oral toxicity study in
rats (BASF, 1980). Therefore, the oral absorption of
2-aminoethyldiethylamine can be assumed to be 100% for risk assessment.
Inhalation route
According to the REACH Guidance, the physicochemical characteristics of
2-aminoethyldiethylamine and the molecular mass are in a range
suggestive of absorption as such from the respiratory tract subsequent
to inhalation exposure. This assumption is supported by the mortality
observed in rats exposed for 4 hours to an atmosphere saturated with
vapours of 2-aminoethyldiethylamine (BASF, 1980). Therefore, the
inhalation absorption of 2-aminoethyldiethylamine can be assumed to be
100% for risk assessment.
Dermal absorption
According to the REACH Guidance, the n-Octanol/water partition
coefficient, the water solubility and molecular weight of
2-aminoethyldiethylamine are in ranges which favour dermal absorption.
DISTRIBUTION and METABOLISM
According to the REACH Guidance, as a small molecule a wide
distribution of 2-aminoethyldiethylamine is expected. In general, lower
primary aliphatic amines are metabolized to the corresponding carboxylic
acid and urea. N-oxide formation and excretion of both freebase and
N-oxide forms, with a small quantity undergoing dealkylation, appears to
be the major route of excretion for the lower molecular weight tertiary
amines.
ELIMINATION
According to the REACH Guidance, the n-Octanol/water partition
coefficient is not suggestive of accumulation of unchanged
2-aminoethyldiethylamine in fatty tissues subsequent to absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
