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Description of key information

No data on toxicokinetics, metabolism and distribution are available for 2-aminoethyldiethylamine. Based on the available toxicological studies and the physico-chemical properties, particularly water solubility and octanol-water partition coefficient, absorption via oral, inhalative and dermal route a respective assessment is possible.  The test substance is expected to be well absorbed by the respiratory and gastro-intestinal tracts and through the skin.The target test substance is assumed to be widely distributed and comprehensively metabolized. If not excreted unchanged, excretion of the metabolites may occur predominantly via the urine. The test substance is not expected to accumulate and there is no evidence for a (sex-)specific toxic effect.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The assessment of the toxicokinetics of 2-aminoethyldiethylamine is based primary on the available toxicological data and the physicochemical properties as suggested by the REACH Guidance Chapter R.7c.
Molecular weight: 116.2 g/mol
Water solubility: miscible
Partition coefficient log Kow = 0.1 at 25 °C

ABSORPTION
Oral route
According to the REACH Guidance, the physicochemical characteristics of 2-aminoethyldiethylamine and the molecular mass are in a range suggestive of absorption as such from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is supported by the mortality observed in the acute oral toxicity study in rats (BASF, 1980). Therefore, the oral absorption of 2-aminoethyldiethylamine can be assumed to be 100% for risk assessment.
Inhalation route
According to the REACH Guidance, the physicochemical characteristics of 2-aminoethyldiethylamine and the molecular mass are in a range suggestive of absorption as such from the respiratory tract subsequent to inhalation exposure. This assumption is supported by the mortality observed in rats exposed for 4 hours to an atmosphere saturated with vapours of 2-aminoethyldiethylamine (BASF, 1980). Therefore, the inhalation absorption of 2-aminoethyldiethylamine can be assumed to be 100% for risk assessment.
Dermal absorption
According to the REACH Guidance, the n-Octanol/water partition coefficient, the water solubility and molecular weight of 2-aminoethyldiethylamine are in ranges which favour dermal absorption.


DISTRIBUTION and METABOLISM
According to the REACH Guidance, as a small molecule a wide distribution of 2-aminoethyldiethylamine is expected. In general, lower primary aliphatic amines are metabolized to the corresponding carboxylic acid and urea. N-oxide formation and excretion of both freebase and N-oxide forms, with a small quantity undergoing dealkylation, appears to be the major route of excretion for the lower molecular weight tertiary amines.


ELIMINATION
According to the REACH Guidance, the n-Octanol/water partition coefficient is not suggestive of accumulation of unchanged 2-aminoethyldiethylamine in fatty tissues subsequent to absorption.