Registration Dossier
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EC number: 218-664-7 | CAS number: 2212-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
The in vitro rate of metabolism was determined for [1,3(or 1,4)- Phenylenebis(1-methylethylidene)] bis[tert-butyl] peroxide using thein vitrometabolism trout liver S9 assay (OECD Test Guideline 319B, adopted in June 2018).
This organic peroxide metabolized rapidly under biologically active conditions with a metabolic half- life of 67 minutes or 1.13 hours. This data was used to extrapolatein vivorate constants of metabolism or kMETof 0.184 day-1or 0.475 day-1using hepatic portal blood flow or hepatic portal and arterial blood flow, respectively. The use of these kMET values in conjunction with the Gobas model dropped the calculated BCF from 45,294 kg day-1(assuming no metabolism) to 536 or 209 kg day-1. The impact of metabolism on [1,3(or 1,4)- Phenylenebis(1-methylethylidene)] bis[tert-butyl] peroxide drops the BCF to less than the action level of 2000 (Reach Criteria) and should not be considered to have significant bioaccumulation potential.
A bioacucmulation in fish study according to the OECD 305 Test Guideline using aqueous exposure will be performed on analog 25155 -25 -3 and submitted later based on ECHA decision number SEV-D-2114369067-43-01/F.
Key value for chemical safety assessment
- BCF (aquatic species):
- 536 L/kg ww
Additional information
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