Registration Dossier

Administrative data

Description of key information

- Skin irritation: not irritating (kr 2, similar to OECD 404)
- Eye irritation: not irritating (kr 2, similar to OECD 405)

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Skin irritation/corrosion

A key study was identified (Gonnet and Guillot, 1981). In a dermal irritation study performed similarly to the OECD test guideline No. 404 (Draize test), 4 New Zealand White rabbits were exposed to 0.5 mL of undiluted Cis-pentene-2 nitrile commercial. Test sites were covered with an occlusive dressing for 24 hours and weren’t washed after this period. Changes were observed at 25 and 72 hours. Mean score were 0.0 for erythema and edema. These data are supported by Sarver, 1990 study results.

 

Eye irritation

A key study was identified (Gonnet and Guillot, 1981). In an eye irritation study performed similarly to the OECD test guideline No. 405, 0.1 mL of undiluted cis-2-Pentenenitrile commercial was instilled into the conjunctival sac of left eye of 4 New Zealand White rabbits. The eyes of the animals were not washed after instillation. Eyes were examined at 1, 24, 48, 72, 96 and 168 hours after dosing and grading according to Draize scale. Cis-2-Pentenenitrile produced slight chemosis (mean score 0.25), slight conjunctival redness (mean score 0.2), and slight corneal lesions (mean score 0.25) which were completely reversed after 2 days. Iris lesions (mean score 0.6) were not completely reversed after 7 days.

These data are supported by Malek, 1990 study results.

Justification for classification or non-classification

As no signs of skin irritation were observed in a dermal irritation study with cis-2-pentenenitrile conducted similarly to OECD test guideline No. 404, cis-2-pentenenitrile is not classified as irritating to the skin according to the Directive 67/548/EC and the CLP Regulation (1272/2008).

Since only slight signs of eye irritation were observed in an eye irritation study with cis-2-pentenenitrile conducted similarly to the OECD test guideline No. 405, cis-2-pentenenitrile is not classified as irritating to eyes according to the Directive 67/548/EC and the CLP Regulation (1272/2008).