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EC number: 220-778-7 | CAS number: 2896-70-0
A GLP study was performed to assess the toxicity of 2,2,6,6-tetramethyl-4-oxopiperidinooxy when administered orally. The study was performed in accordance with OECD guideline 401. Following a range finding study, three groups of five fasted females were dosed with a single dose of test material. The doses were administered as a dispersion in water at levels of 1000, 1414 and 2000mg/kg/b w. An additional group of five fasted males were treated with 2000mg/kg/bw in order to illustrate that one sex was not more sensitive that the other. The animals were observed for 14 days after dosing. All animals were subject to a gross pathological examination.
All animals, male and female, in the high dose group died by day 4, two animals in the 1414mg/kg/bw dose group died, one on day 1 and the other day 4, no deaths were observed in the 1000mg/kg/bw group. Common signs of systemic toxicity noted were ataxia, hunched posture, lethargy, ptosis, decreased respiratory rate and laboured respiration with additional signs or incidents of clonic or tonic convulsions, pilo-erection, loss of righting reflex, occasional body tremors and splayed gait.
Surviving animals recovered two days after dosing except for one female which appeared normal throughout the study. No abnormality was observed with respect to weight gain.
Abnormalities noted at necropsy of animals that died during the course of the study were haemorrhagic or abnormally red lungs, ark liver and dark kidneys. No abnormalities were observed in animals that were terminated at the end of the study.
The acute oral median lethal dose and 95% confidence limits were calculated by the method of Thompson W R to be 1464 (1235 – 1735) mg/kg/bw for females only.
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