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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP screening study
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Principles of method if other than guideline:
study in the rabbit
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide
EC Number:
257-027-8
EC Name:
2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide
Cas Number:
51167-18-1
Molecular formula:
C14H20Cl2N2O2
IUPAC Name:
N'-[2,4-dichloro-5-(propan-2-yloxy)phenyl]-2,2-dimethylpropanehydrazide
Details on test material:
- Name of test material (as cited in study report): 1-(2,4-dichloro 5-isopropoxy phenyl) 2-trimethylacetyl hydrazine (DIPTH)
- Storage condition of test material: stored in the dark at room temperature in air-tight containers

Test animals

Species:
rabbit

Results and discussion

In vivo

Irritant / corrosive response data:
no indication of irritation to skin

Any other information on results incl. tables

No further indication of the test results provided

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the test conditions, 2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide is not classified for skin irritation.
Executive summary:

In an in vivo skin irritation screening test performed in compliance with the GLP, 2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide (named as 1-(2,4-dichloro 5-isopropoxy phenyl) 2-trimethylacetyl hydrazine (DIPTH)) induced no skin irritation. It can be therefore concluded that it is not classified for skin irritation.