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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

The toxicity of 1,3-diphenyl-2-thiourea was tested on Daphnia magna reproduction according to the OECD 211 guideline. The NOEC was 0.15 mg/L.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.15 mg/L

Additional information

This study was designed to determine the effects of 1,3 -diphenyl-2 -thiourea on Daphnia magna reproduction and survival in a 21 days test according to the OECD 211 Guideline. The total test period was 21 days; all test solutions (including control) were renewed every day (including "weekend" periods). Ten replicate test vessels were prepared for the control and the test concentration. A single juvenile Daphnia magna (<24 hours old selected by filtration) was added to each test vessel. Each day, parental animals were transferred into freshly prepared test media. Dead parents were noted and discarded. All produced juveniles were counted every day. Chemical analysis of test samples confirmed the stability of the substance over a 24-hour test period. Based on these results, the exposure concentrations were based on the nominal concentration. NOEC and LOEC values on day 21 were determined as follows:

NOEC for mean number of neonate produced per parent alive at the end of the test: 0.15 mg/L

NOEC for mobility: 1.56 mg/L

NOEC for age at first reproduction: > 5 mg/L.