Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 927-344-2 | CAS number: -
Specific investigations: other studies
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to basic scientific principles.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- specific investigations: other studies
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to basic scientific principles.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were exposed for 4 h/day, for 4 consecutive days and the upper airway was examined.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
- Species:
- rat
- Strain:
- other: CDI
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Two groups of 6 female CDI rats (Charles River U.K. Ltd.), weighing between 150 and 200 g, were randomly selected from a batch of 24 animals on arrival at the laboratory. Animals, caged in groups of 3 in plastic grid-bottomed cages were housed in a temperature controlled room (21-24°C: and allowed unlimited access to pelletted laboratory diet (Labsure PRD) and mains tap water. The animals were acclimatized to the laboratory for 5 days prior to the start of the study.
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- head only exposure
- Executive summary:
Exposure of rats to atmospheres containing an average of 214 mg/m3, 4 h/day, for 4 consecutive days resulted in irritation of the membranes lining the upper respiratory tract but only minimal signs of lung injury. Histopathological changes were observed in the nasal cavity, trachea and larynx and included loss of cilia, mucous and basal cell hyperplasia and squamous metaplasia.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were exposed for 4 h/day, for 4 consecutive days and the upper airway was examined.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Details on test material:
- The white spirit used for this study was a commercial-grade solvent which consisted of approx. 61% paraffins, 20% naphthenes and 19% aromatics. The mixture contained mainly C9-C12 hydrocarbons and its boiling point range was l50-l95°C.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CDI
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Two groups of 6 female CDI rats (Charles River U.K. Ltd.), weighing between 150 and 200 g, were randomly selected from a batch of 24 animals on arrival at the laboratory. Animals, caged in groups of 3 in plastic grid-bottomed cages were housed in a temperature controlled room (21-24°C: and allowed unlimited access to pelletted laboratory diet (Labsure PRD) and mains tap water. The animals were acclimatized to the laboratory for 5 days prior to the start of the study.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- head only exposure
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Exposure of rats to atmospheres containing an average of 214 mg/m3, 4 h/day, for 4 consecutive days resulted in irritation of the membranes lining the upper respiratory tract but only minimal signs of lung injury. Histopathological changes were observed in the nasal cavity, trachea and larynx and included loss of cilia, mucous and basal cell hyperplasia and squamous metaplasia.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
