Registration Dossier
Registration Dossier
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EC number: 220-481-2 | CAS number: 2781-10-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The following study has been submitted to address the toxicity to algae and cyanobacteria endpoint on the structural analogue DBTO:
Steger-Hartmann T (1999). Growth inhibition test of di-n-butyltin oxide (ZK 26385) on the green algae Scenedesmus subspicatus. Testing laboratory: Schering AG, Experimentelle Toxikologie, D-13342 Berlin, Germany. Report no.: IC28. Owner company: Schering AG, Experimentelle Toxikologie, Berlin, Germany. Study number: TXST19980234. Report date: 1999-02-17. The EC50 was found to be 1.6 mg/L.
The study has been allocated a Klimisch score of 1 and is the key study for this endpoint.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 1.6 mg/L
Additional information
The key study is available to the registrant conducted on the structurally analogous substance DBTO. Steger-Hartmann T (1999) was provided as the key study for the endpoint. The study was performed in accordance with the OECD guideline 201. The study was therefore assigned a reliability score of 1 and considered adequate for the assessment of the toxicity of the test material to algae. Di-n-butyltin oxide was incubated in an aqueous solution including nutrients with an algae population of Scendesmus subspicatus for a test duration of 72 hours. The increase in biomass and growth rate of each concentration were compared to those of the controls, and the inhibition was calculated. The observed reduction in growth was not prominent and showed no concentration-dependence. It was therefore interpreted as not being substance-related. the biomass and growth rates could not be calculated. A saturated solution of di-n-butyltin oxide is not toxic to the green algae Scenedesmus subspicatus.
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