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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Administrative data

Description of key information

No carcinogenicity data available.

Key value for chemical safety assessment

Justification for classification or non-classification

Additional information

Thiodiglycol did not induce mutations in bacteria or mouse lymphoma cells with or without addition of a metabolic activation system. At high dose levels which resulted in cytotoxic effects, thiodiglycol induced chromosome aberrations in vitro, both in the presence and the absence of a metabolic activation system. No clastogenic activity was detected in the mouse bone marrow micronucleus assay at oral doses up to and including 2000 mg/kg bw. It is therefore concluded that the clastogenic effects seen in vitro are not expressed in vivo. Based on the available genotoxicity data, there is no hint for any carcinogenic potential.