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Toxicological information

Carcinogenicity

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Description of key information

No carcinogenicity data available.

Key value for chemical safety assessment

Justification for classification or non-classification

Additional information

Thiodiglycol did not induce mutations in bacteria or mouse lymphoma cells with or without addition of a metabolic activation system. At high dose levels which resulted in cytotoxic effects, thiodiglycol induced chromosome aberrations in vitro, both in the presence and the absence of a metabolic activation system. No clastogenic activity was detected in the mouse bone marrow micronucleus assay at oral doses up to and including 2000 mg/kg bw. It is therefore concluded that the clastogenic effects seen in vitro are not expressed in vivo. Based on the available genotoxicity data, there is no hint for any carcinogenic potential.