Registration Dossier
Registration Dossier
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EC number: 208-859-5 | CAS number: 544-10-5
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of chlorinated alkanes on hepatic triglyceride secretion
- Author:
- Selan, F.M. and Evans, M.A.
- Year:
- 1 987
- Bibliographic source:
- Res. Comm. Chem. Pathol. Pharmacol., 55(2), 249-269, Feb. 1987
Materials and methods
- Principles of method if other than guideline:
- Specific test design.
Test material
- Reference substance name:
- 1-chlorohexane
- EC Number:
- 208-859-5
- EC Name:
- 1-chlorohexane
- Cas Number:
- 544-10-5
- Molecular formula:
- C6H13Cl
- IUPAC Name:
- 1-chlorohexane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
Administration / exposure
- Route of administration:
- other: oral, gavage
- Vehicle:
- other: corn oil
- Duration of treatment / exposure:
- Exposure period: 2 hour(s)
- No. of animals per sex per dose:
- 4
Results and discussion
Any other information on results incl. tables
In vivo, ID50 was apparently inversely related to the lipophilicity of the
compounds: those with the longer carbon chain and less chlorine substituents
were less inhibitory on TG release from the liver.
For 1-chlorohexane, the mean ID50 (after 2 h post-treatment) was high at 7.6 g/kg.
Applicant's summary and conclusion
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