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Stability in organic solvents and identity of relevant degradation products

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Reference
Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
other: An expert assessment has been conducted using existing data and literature sources in an attempt to identify likely degradation products
Adequacy of study:
key study
Study period:
2020
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An expert assessment has been conducted using existing data and literature sources in an attempt to identify likely degradation products
Qualifier:
no guideline followed
Principles of method if other than guideline:
An expert assessment has been conducted using existing data and literature sources in an attempt to identify likely degradation products by assessing the two constituent compounds separately and considering their likely environmental fate.
GLP compliance:
no
Test substance stable:
not determined
Remarks:
An expert assessment has been conducted using existing data and literature sources in an attempt to identify likely degradation products by assessing the two constituent compounds separately and considering their likely environmental fate.
Conclusions:
6-[(p-tosyl)amino] hexanoic acid has been shown to be ultimately biodegradable over a
period of 28 days, with 4-aminobutyric acid and 4-N-p-tosyl glycine identified as degradation
products.
2,2’,2’’-nitriloethanol has been demonstrated to be readily biodegradable in a variety of
environmental compartments. The compound can be used by microorganisms as a source
of carbon and nitrogen and is ultimately expected to be completely transformed/biodegraded
over a relatively short period. Transient degradation products of diethanolamine and
ethanolamine are expected with the release of acetaldehyde.
6 I.
Executive summary:

An assessment of likely degradation products has been performed by considering each of the constituent compounds in the title substance 6-[(p-tosyl)amino] hexanoic acid, compound with 2,2’,2’’-nitriloethanol (1:1) separately. The assessment has been performed by referring to existing experimental studies and literature sources.
6-[(p-tosyl)amino] hexanoic acid has been shown to be ultimately biodegradable over a period of 28 days, with 4-aminobutyric acid and 4-N-p-tosyl glycine identified as degradation products.
2,2’,2’’-nitriloethanol has been demonstrated to be readily biodegradable in a variety of environmental compartments. The compound can be used by microorganisms as a source of carbon and nitrogen and is ultimately expected to be completely transformed/biodegraded over a relatively short period. Transient degradation products of diethanolamine and ethanolamine are expected with the release of acetaldehyde.

Description of key information

An assessment of likely degradation products has been performed by considering each of the constituent compounds in the title substance 6-[(p-tosyl)amino] hexanoic acid, compound with 2,2’,2’’-nitriloethanol (1:1) separately. The assessment has been performed by referring to existing experimental studies and literature sources.
6-[(p-tosyl)amino] hexanoic acid has been shown to be ultimately biodegradable over a period of 28 days, with 4-aminobutyric acid and 4-N-p-tosyl glycine identified as degradation products.
2,2’,2’’-nitriloethanol has been demonstrated to be readily biodegradable in a variety of environmental compartments. The compound can be used by microorganisms as a source of carbon and nitrogen and is ultimately expected to be completely transformed/biodegraded over a relatively short period. Transient degradation products of diethanolamine and ethanolamine are expected with the release of acetaldehyde.

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