Registration Dossier
Registration Dossier
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EC number: 220-491-7 | CAS number: 2783-94-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- BIBRA toxicity profile of sunset yellow FCF
- Author:
- The British Industrial Biological Research Agency
- Year:
- 1 995
- Bibliographic source:
- BIBRA Report (1995), (Order No. BIBRA196GAR), 6 pp
Materials and methods
- Principles of method if other than guideline:
- The eye irritation study was conducted to evaluate the irritating effects of administration of sunset yellow FCF to eye of rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate
- EC Number:
- 220-491-7
- EC Name:
- Disodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate
- Cas Number:
- 2783-94-0
- Molecular formula:
- C16H12N2O7S2.2Na
- IUPAC Name:
- disodium 6-hydroxy-5-[(4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate
- Details on test material:
- - Name of test material: sunset yellow FCF
- Molecular formula: C16H12N2O7S2.2Na
- Molecular weight: 454.38
- Substance type: organic
- Physical state: solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- other: minimally irritant to the rabbit eye
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Disodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate (sunset yellow FCF) was found to be minimally irritant to the rabbit eye which is not enough to classify as eye irritant thus test substance was considered to be non irritant to eye of rabbit.
- Executive summary:
Disodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate (sunset yellow FCF) was found to be minimally irritant to the rabbit eye which is not enough to classify as eye irritant thus test substance was considered to be non irritant to eye of rabbit.
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