Registration Dossier
Registration Dossier
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EC number: 220-491-7 | CAS number: 2783-94-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The estimated lethal NR-ZERO of disodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate for Paramecium caudatum for 0.33 hours using QSAR toolbox is 0.325 percent. Based on this value it can be concluded that the substance disodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate is considered to be not toxic to aquatic enviornment.
Key value for chemical safety assessment
Additional information
No. of studies were reviewed for toxicity to microorganisms from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1. |
NR-ZERO |
0.325mg/L |
Mortality |
0.3333333 hrs. |
Paramecium caudatum |
Predicted data from QSAR |
2. |
IGC50 |
17.606mg/l |
growth inhibition |
46 hrs. |
Tetrahymena pyriformis |
Predicted data from Danish QSAR |
3. |
EC50 |
22.1 mg/L |
inhibition of light output |
5 min |
Vibrio fisheri |
Experimental data from Journal of Biotechnology |
Based on the studies summarized in the above table for the target substance disodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate, the endpoint value was found to be EC50 = 22.1 mg/L; IGC50 = 17.606mg/l and NR-ZERO =0.325mg/L in 5 min. to 46 hrs. Study on the basis of inhibition of light output, growth inhibition and Mortality effect.
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