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EC number: 940-029-4 | CAS number: 1474044-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the O.E.C.D. test guideline 203 with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,3-epoxypropyl neodecanoate
- EC Number:
- 247-979-2
- EC Name:
- 2,3-epoxypropyl neodecanoate
- Cas Number:
- 26761-45-5
- Molecular formula:
- C13H24O3
- IUPAC Name:
- Oxiran-2-ylmethyl 2-ethyl-2,5-dimethylhexanoate
- Reference substance name:
- Neodecanoic acid, oxiranylmethyl ester
- IUPAC Name:
- Neodecanoic acid, oxiranylmethyl ester
- Test material form:
- other: Colorless liquid at room temperature.
- Details on test material:
- As per IUCLID5 Sections 1.1. 1.2. 1.4. and 4.1. for 2,3-epoxypropyl neodecanoate, REACH Registration: 01-2119431597-33-0000.
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
As per IUCLID5 Sections 1.1. 1.2. 1.4. and 4.1. for 2,3-epoxypropyl neodecanoate, REACH Registration: 01-2119431597-33-0000.
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Stock solutions of 2,3-epoxypropyl neodecanoate were prepared in Analar acetone to yield final nominal concentrations of 1, 2, 5, 10, 20 and 50 mg/L when added to the treatment vessels. The final concentration of acetone was 0.1 ml/L.
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Healthy S. gairdneri (rainbow trout) fingerlings were obtained from Itchen Valley Trout Farm, Airesford, Hampshire and acclimated to the test conditions for more than 10 days before use. A sample of ten of the fish used in the test had a mean length of 5.0 cm (range 4.4 to 5.9 cm) and a mean weight of .1.5 gm (range 0.9 to 2.3 gm).
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- None.
Test conditions
- Hardness:
- Total hardness of the water was 250—270 mg/L as CaCO3. and the concentration of dissolved oxygen was 10.2—10.6 tug l1
- Test temperature:
- 15 ÷ 2°C
- pH:
- 7.5—8.1
- Dissolved oxygen:
- concentration of dissolved oxygen was 10.2—10.6 mg/L.
- Salinity:
- No data
- Nominal and measured concentrations:
- 1, 2, 5, 10, 20 and 50 mg/L nominal.
- Details on test conditions:
- A 96h semi-static toxicity test was carried out with rainbow trout with daily renewal of the test solutions. Seven glass aquaria were filled with 20 litresof filtered dechlorinated mains water. Quantities of a stock solution of 2,3-epoxypropyl neodecanoate in Analar acetone were added to six of these to give an approximately logarithmic series of concentrations between 1 and 50 mg/ L. The seventh aquarium received no test substance and served as a control. Ten rainbow trout were placed in each aquarium. The fish were not fed during the test. The aquaria were gently aerated to maintain the concentrations of dissolved oxygen. At 24h intervals the number of dead fish was recorded and any dead removed, dissolved oxygen concentration and pH were measured and the test solutions were renewed.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortalities were observed at 1 and 2 mg/L. 5/10 of the fish were dead at 5 mg/L after 96 hr of treatment. Complete mortality (10/10) occured at 10, 20 and 50 mg/L. At the two highests concentration of test substance of 20 and 50 mg/L complete mortality ( 0 % survival) was observed after 24 hr of exposure.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
- Globules of undissolved test substance, 2,3 -epoxypropyl neodecanoate were present on the surface of the water at all test concentrations. The test substance was therefore not wholly soluble at any of the concentrations tested.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 hr LC50 of rainbow trout was estimated to be 5 mg/L.
- Executive summary:
The acute 96 hr acute toxicity of the test substance, 2,3-epoxypropyl neodecanoate was determined by an O.E.C.D. test guideline 203 study. The 96 hr LC50 of rainbow trout was estimated to be 5 mg/L. Therefore, Neononanoic acid glycidyl ester is anticipated to have a similar rainbow trout LC50 value under the conditions of this study.
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