Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Alchisor CAL 145 comprises alkenes C13-14 hydroformylation products and read-across from the chemically-similar Alchisor CAL 123 has been used in this hazard assessment as defined in the `Read-Across Justification Document'. Where environmental toxicity data exist for Alchisor CAL 123, these are representative of the Alchisor CAL 145 substance. Reliable data were available for short-term toxicity to invertebrates, short-term toxicity to fish, toxicity to algae and toxicity to microorganisms. In a conservative approach the most sensitive study result related to each endpoint was chosen as Key and is summarized below. There were no reliable long-term toxicity data for fish, invertebrates or aquatic plants therefore a waiver is being applied for these endpoints. 

Short-term Toxicity to Fish

The short-term toxicity of Alchisor 145, based on read-across from Alchisor CAL 123, to fish has been evaluated for this dossier. One reliable (Klimisch 1; Klimisch 2 when used for read-across) short-term toxicity study for fish was available for Alchisor CAL 123. The short-term toxicity of Alchisor CAL 123 to the fathead minnow (Pimephales promelas) was reported by Claude & Krueger (2010) in an OECD 203 guideline and GLP compliant study. Fish were exposed to the test substance in measured concentrations for 96 hours, resulting in a 96-hr LC50 of >100 mg/L. This reliable study result is designated as Key for the short-term toxicity to fish endpoint.

Long-term Toxicity to Fish

In accordance with REACH Annex IX, the requirement for long-term toxicity to fish is waived on the basis that the substance is readily biodegradable and has low toxicity to aquatic life. No reliable predicted or measured long-term toxicity to fish data are available for Alchisor CAL 145 (or Alchisor CAL 123).

Short-term Toxicity to Invertebrates

The short-term toxicity of Alchisor CAL 145, based on read-across from Alchisor CAL 123, to invertebrates has been evaluated for this dossier. One reliable (Klimisch 1; Klimisch 2 when used for read-across) short-term toxicity study for invertebrates was available for Alchisor CAL 123. The short-term toxicity of Alchisor CAL 123 to Daphnia magna was reported by Claude & Krueger (2010) in an OECD 202 guideline and GLP compliant study. Daphnia were exposed to the test substance in measured concentrations for 48 hours, resulting in a 48-hr LC50 of >100 mg/L. This reliable study result is designated as Key for the short-term toxicity to invertebrates endpoint.

Long-term Toxicity to Invertebrates

In accordance with REACH Annex IX, the requirement for long-term toxicity to invertebrates is waived on the basis that the substance is readily biodegradable and has low toxicity to aquatic life. No reliable predicted or measured long-term toxicity to invertebrates data are available for Alchisor CAL 145 (or Alchisor CAL 123).

Toxicity to Aquatic Algae

The toxicity of Alchisor CAL 145, based on read-across from Alchisor CAL 123, to aquatic algae and bacteria has been evaluated for this dossier. One reliable (Klimisch 1; Klimisch 2 when used for read-across) toxicity study for aquatic algae was available for Alchisor CAL 123. The toxicity of Alchisor CAL 123 to Pseudokirchnerella subcapitata was reported by Porch & Krueger (2010) in an OECD 201 guideline and GLP compliant study. Algae was exposed to the test substance in measured concentrations for 72 hours, resulting in a 72-hr LC50 of 35 mg/L, based on cell density and yield. The 72-hr NOEC, based on growth rate, was 25 mg/L. This reliable study result is designated as Key for the toxicity to aquatic algae endpoint.

Toxicity to Microorganisms

The toxicity of Alchisor CAL 145, based on read-across from Alchisor CAL 123, to microorganisms has been evaluated for this dossier. One reliable (Klimisch 1; Klimisch 2 when used for read-across) toxicity study for microorganisms was available for Alchisor CAL 123. The toxicity of Alchisor CAL 123 to activated sludge was reported by Schaefer & Twilly (2010) in an OECD 209 guideline and GLP compliant study. Activated sludge was exposed to nominal concentrations of the test substance for 3 hours, resulting in a 3 -hr LC50 of >1,000 mg/L, based on respiration. This reliable study result is designated as Key for the toxicity to microorganisms endpoint.

Study data for Alchisor CAL 145, where available using read-across from Alchisor CAL 123, has been evaluated and considered for assessment. Reliable data was available for short-term toxicity to invertebrates, short-term toxicity to fish, toxicity to algae, and toxicity to microorganisms. No reliable long-term data for fish or invertebrates were available. Data requirements for long-term toxicity data for fish, invertebrates and aquatic plants are waived.