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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1965
Report Date:
1965

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,2-Dimethylimidazol
- Physical state: solid

Test animals

Species:
mouse
Strain:
other: Kisslegg
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
200, 250, 320, 400, 800, 1600 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 300 mg/kg bw
Based on:
test mat.
Mortality:
0/10 animals died at 200 mg/kg bw
0/10 animals died at 250 mg/kg bw
7/10 animals died at 320 mg/kg bw
8/10 animals died at 400 mg/kg bw
10/10 animals died at 800 mg/kg bw
10/10 animals died at 1600 mg/kg bw
deaths occured within day 1
Clinical signs:
Immediately until a few minutes after the injection, jumping, tremor, flexor, extensor spasms, dyspnea, cyanosis, abdominal or side position, convulsive spasms, convulsions, crying, extremity cramps. Cramp occurred within one hour. The survivors were partly apathetic after 2 hours with convulsive twitches, prone position. In the following days calm demeanor, shaggy coat were observed. After 6-7 days no symptoms were observed.
Gross pathology:
Animals dead during study: severe redness around injection site, partial pale livers
Animals sacrificed after study: no findings

Applicant's summary and conclusion