2,3-epoxypropyl phenyl ether

Genetic toxicity: in vivo

Administrative data

Endpoint:

in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus

Remarks:

Type of genotoxicity: chromosome aberration

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

The mutagenicity of mono- and di-functional aromatic glycidyl compounds

Author:

Seiler JP

Year:

1984

Bibliographic source:

Mutation Research 135, 159-167

Reference 2

Reference Type:

secondary source

Title:

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

Author:

WHO IARC

Year:

1989

Bibliographic source:

IARC Monographs, Volume 47, 237-261

Reference 3

Reference Type:

secondary source

Title:

Phenyl glycidyl ether

Author:

MAk Commission

Year:

1991

Bibliographic source:

MAK List 1991

Report date:

1991

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)

Deviations:

yes

Remarks:

limited information

GLP compliance:

no

Type of assay:

micronucleus assay

Test material

Test material information

Constituent 1

Reference substance name:

phenylglycidylether

IUPAC Name:

phenylglycidylether

Details on test material:

- Name of test material (as cited in study report): phenylglycidylether
No further data provided.

Test animals

Species:

mouse

Strain:

ICR

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Institute of Animal Husbandry of the University of Zurich
- Weight at study initiation: +/- 25 g
No further data provided.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

- Vehicle(s)/solvent(s) used: polyethylene glycol

Duration of treatment / exposure:

24 hours

Frequency of treatment:

once

Doses / concentrations

Remarks:

Doses / Concentrations:
400, 500, 800, 1000 mg/kg bw
Basis:
actual ingested

No. of animals per sex per dose:

4

Control animals:

not specified

Positive control(s):

No data.

Examinations

Details of tissue and slide preparation:

DETAILS OF SLIDE PREPARATION: 24 h after application, the mice were sacrificed and the bone marrow cells were flushed out into foetal calf serum. In the case of a negative outcome of the test, a second assay was performed with fixation times of 24, 48, and 72 h, resp. After centrifugation at 400 g, the cells were spread onto slides, air-dried and stained with May-Grtinwald/Giemsa.
No further information provided.

Evaluation criteria:

No data.

Statistics:

No data.

Results and discussion

Test results

Sex:

male/female

Genotoxicity:

negative

Remarks:

Frequency of micronucleated erythrocytes per 1000 polychromatic erythrocytes after fixation time of 24, 48, and 72 hours did not exceed 2.

Toxicity:

not specified

Vehicle controls validity:

not specified