Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study with restrictions (limited information of the test conditions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List V
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC
- Year:
- 1 954
- Bibliographic source:
- Arch. Ind. Hyg. Occupational Med. 10, 61-68
- Reference Type:
- secondary source
- Title:
- Experimental Carcinogenicity and Acute Toxicity of Representative Epoxides
- Author:
- Weil CS, Condra N, Haun C, Striegel JA
- Year:
- 1 963
- Bibliographic source:
- Industrial hygiene Journal 305-325
- Reference Type:
- secondary source
- Title:
- Epoxy Compounds
- Author:
- Waechter JM et al.
- Year:
- 2 001
- Bibliographic source:
- Patty´s Toxicology, fifth edition, vol. 6, 1063-1085
- Reference Type:
- secondary source
- Title:
- Phenyl glycidyl ether
- Author:
- MAK Commission
- Year:
- 1 991
- Bibliographic source:
- MAK List 1991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- limited information of the test conditions
- Test type:
- standard acute method
Test material
- Reference substance name:
- phenyl glycidyl ether
- IUPAC Name:
- phenyl glycidyl ether
- Details on test material:
- - Name of test material (as cited in study report): phenyl glycidyl ether
No further data.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: internal breeding
- Weight at study initiation: 90 to 120 g
- Fasting period before study: animals were not fasted
No further information.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water, corn oil, or a 1 % solution of sodium 3,9-diethyl-6-tridecanol sulfate (Tergitol Penetrant 7)
- Doses:
- No data.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- No data.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 260 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 900 - 4 660
- Mortality:
- No data.
- Clinical signs:
- other: No data.
- Gross pathology:
- No data.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
