Registration Dossier
Registration Dossier
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EC number: 215-478-8 | CAS number: 1327-43-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Irritation to the skin was measured by the patch test technique using the albino rabbit.
- GLP compliance:
- no
Test material
- Reference substance name:
- Silicic acid, aluminum sodium salt
- EC Number:
- 215-684-8
- EC Name:
- Silicic acid, aluminum sodium salt
- Cas Number:
- 1344-00-9
- Details on test material:
- - Name of test material (as cited in study report): Zeolex 23A (sodium aluminosilicate)
- Physical state: fine white powder
- Analytical purity: 95-99 weight %
- Impurities (identity and concentrations): 1-5 weight % sodium sulfate
- Other: pH: 9.8-10.6 (5 % water suspension)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded skin area
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Each animal received 0.5 g of the material at each test site.
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 24 and 72 hours after application
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 72 hours
- Score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 72 hours
- Score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 72 hours
- Score:
- 0
- Reversibility:
- other: no effect
Any other information on results incl. tables
No evidence of erythema or edema was observed following topical application of the test materials to the intact or abraded skin of the rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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