Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1995

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2H,3H-thieno[3,4-b][1,4]dioxine-5,7-dicarboxylic acid

EC Number:

605-999-2

Cas Number:

18361-03-0

Molecular formula:

C8H6O6S

IUPAC Name:

2H,3H-thieno[3,4-b][1,4]dioxine-5,7-dicarboxylic acid

Test animals

Species:

rat

Strain:

other: SPF-bred, strain: Hsd Spb:WU

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: 0.9 % NaCl solution

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5 male
5 female

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU