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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

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Description of key information

A measured BCF is not available for icos-1-ene. Log BCF have been calculated on the basis of a log Kow of 10.03 using two QSAR. Calculated log BCF range from 2.04-2.64.

Key value for chemical safety assessment

Additional information

A measured BCF is not available for icos-1 -ene. As the calculated log Kow of icos-1 -ene is >3 the bioaccumulation endpoint cannot be waived. However, ECHA's Guidance on Information Requirements and Chemical Safety Assessment R7c Endpoint Specific Guidance (2008) indicates that before commissioning a new vertebrate test alternative sources of data on the bioaccumulation potential of a chemical should used.

Nonpolar substances have been shown to have a linear relationship between log Kow and BCF in the log Kow range 1 -6. However, at Kow >6 a decreasing relationship is observed. Several QSAR have been developed that calculate the BCF of non-polar, hydrophobic compounds on the basis of their log Kow (e.g. Connell and Hawker, 1988 and USEPA, 2008). Icos-1 -ene falls within the applicability domain of the USEPA QSAR, but slightly outside that of Connell and Hawker. The calculated log BCF range from 2.04 -2.64.

The log Kow of icos-1 -ene has been calculated in KOWWIN (log kow 10.03) and SPARC (log kow 11.65). ECHA's guidance on information requirements and chemical safety assessment - Part C: PBT assessment (2008) states that the aquatic BCF of a substance is probably lower than 2000l/kg if the calculated log Kow is higher than 10. As none of the Kow models have experimental data in this Kow range the reliability of modelled Kow values >10 is not known. However, as both models indicate a log Kow >10 we can conclude that icos-1 -ene is unlikely to bioaccumulate.

Taken together, this information indicates that icos-1 -ene is not expected to bioaccumulate or pose a risk of secondary poisoning.