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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity: Non-GLP, Limit test (Score 2)
Species: Rat, CFHB strain (Wistar derived)
1% w/v suspension in aqueous methylcellulose (1%), administered by oral intubation, dosage volumes 0.64 to 4.0 mg/kg bodyweight.
LD50 and its 95% confidence limits were calculated by the method of Finney, D. J. (1952).Limit test
Acute dermal toxicity: (realiable without restriction score 1)
Key study according to GLP and in compliance with Directive 84/449 EEC, OECD Guideline No. 402 Method B.3
Species: Rat, Spague-Dawley CFY Strain
Type of coverage: Semi occlusive
Vehicle: Arachis Oil
Doses: 889 mg/kg, 1333 mg/kg, 3000 mg/kg

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
13.9 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
1 662 mg/kg bw

Additional information

Acute oral tox.: LD50= 12.7 mg/kg for males

LD50= 20.1 mg/kg for females

LD50= 13.9 mg/kg males & females                    

  95% CL

Acute dermal tox.: LD50= 1102 mg/kg for males                 651 -1866

LD50= 2529 mg/kg for females               1448 -4419

LD50= 1662 mg/kg males & females        1231 -2244

Justification for classification or non-classification

Acute oral toxicity:

GHS/CLP classification: LD50 > 5 < 50 mg/kg Category 2

LD50 = 13.9 mg/kg (acute oral toxicity rat)

Acute dermal toxicity:

GHS/CLP classification: LD50 < 1000 mg/kg < 2000 mg/kg Category 4

LD50 = 1662 mg/kg (acute dermal toxicity rat)