Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

basic toxicokinetics in vitro / ex vivo
Adequacy of study:
key study
Objective of study:
other: Assessment of toxicokinetic behaviour
In conclusion, no bioaccumulation potential based on study results is concluded.

Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Effects following repeat oral exposure confirm that absorption takes place and adaptive changes indicated by effects on enzymes would suggest that a certain level of metabolism is taking place. The substance quickly loses its identity in water and it is probable that exposure to animals is to the breakdown products. The breakdown products are water soluble and are thought unlikely to accumulate. Changes in the kidney in the repeat dose study indicate that the substance or its metabolites passes through the kidney, but there is no evidence as to whether renal excretion takes place.