Pentan-2-one

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-pentanone

IUPAC Name:

2-pentanone

Constituent 2

Reference substance name:

methyl n-propyl ketone

IUPAC Name:

methyl n-propyl ketone

Constituent 3

Reference substance name:

Pentan-2-one

EC Number:

203-528-1

EC Name:

Pentan-2-one

Cas Number:

107-87-9

Molecular formula:

C5H10O

IUPAC Name:

pentan-2-one

Test material form:

other: liquid

Test animals

Species:

guinea pig

Strain:

not specified

Test system

Type of coverage:

semiocclusive

Preparation of test site:

not specified

Vehicle:

not specified

Results and discussion

In vivo

Results

Irritation parameter:

other:

Basis:

other:

Remarks on result:

other: Scoring was based on observation and not done with a numerical scale

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

Methyl n-propyl ketone was considered to be a skin irritant.

Executive summary:

Methyl n-propyl ketone was applied to the skin of Guinea Pigs. The test article was considered to be a slight skin irritant.