Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: As this study was pre-GLP, detail in the report is lacking but the study was conducted in a state-of-the-art facility to the standards of the time.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Test material form:
other: liquid

Test animals

Species:
guinea pig
Strain:
not specified

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
other:
Basis:
other:
Remarks on result:
other: Scoring was based on observation and not done with a numerical scale

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Methyl n-propyl ketone was considered to be a slight skin irritant.
Executive summary:

Methyl n-propyl ketone was applied to the skin of Guinea Pigs. The test article was considered to be a slight skin irritant.