Pentan-2-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

Principles of method if other than guideline:

The study guideline was equivlaent to the OECD 401 study.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Pentan-2-one

EC Number:

203-528-1

EC Name:

Pentan-2-one

Cas Number:

107-87-9

Molecular formula:

C5H10O

IUPAC Name:

pentan-2-one

Constituent 2

Reference substance name:

2-pentanone

IUPAC Name:

2-pentanone

Constituent 3

Reference substance name:

Methyl n-propyl ketone

IUPAC Name:

Methyl n-propyl ketone

Test material form:

other: Liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Animals were given a single oral dose of the test article.

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 1 600 - < 3 200 mg/kg bw

Applicant's summary and conclusion

Conclusions:

The LD50 of the study was given as 1600-3200 mg/kg.

Executive summary:

Groups of rats were treated with methyl propyl ketone by oral gavage. The reported LD50 was 1600 -3200 mg/kg.